Population Pharmacokinetics of Isavuconazole from Phase 1 and Phase 3 (SECURE) Trials in Adults and Target Attainment in Patients with Invasive Infections Due to Aspergillus and Other Filamentous Fungi

Isavuconazole, the active moiety of the water-soluble prodrug isavuconazonium sulfate, is a triazole antifungal agent used for the treatment of invasive fungal infections. The objective of this analysis was to develop a population pharmacokinetic (PPK) model to identify covariates that affect isavuc...

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Detalles Bibliográficos
Autores principales: Desai, Amit, Kovanda, Laura, Kowalski, Donna, Lu, Qiaoyang, Townsend, Robert, Bonate, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997882/
https://www.ncbi.nlm.nih.gov/pubmed/27381396
http://dx.doi.org/10.1128/AAC.02819-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997882/
https://www.ncbi.nlm.nih.gov/pubmed/27381396
http://dx.doi.org/10.1128/AAC.02819-15

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