Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells

Cisplatin is a known antitumor drug, but its mechanisms of action are not fully elucidated. In this research, we studied the anticancer potential of cisplatin at doses of 1, 2, or 3 µM using HL-60 cells as a test model. We investigated cisplatin effects at the molecular level using RNA sequencing, c...

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Detalles Bibliográficos
Autores principales: Velma, Venkatramreddy, Dasari, Shaloam R., Tchounwou, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998075/
https://www.ncbi.nlm.nih.gov/pubmed/27594783
http://dx.doi.org/10.4137/BMI.S39445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998075/
https://www.ncbi.nlm.nih.gov/pubmed/27594783
http://dx.doi.org/10.4137/BMI.S39445

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