Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis

PURPOSE: Lens glutathione synthesis knockout (LEGSKO) mouse lenses lack de novo glutathione (GSH) synthesis but still maintain >1 mM GSH. We sought to determine the source of this residual GSH and the mechanism by which it accumulates in the lens. METHODS: Levels of GSH, glutathione disulfide (GS...

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Detalles Bibliográficos
Autores principales: Whitson, Jeremy A., Sell, David R., Goodman, Michael C., Monnier, Vincent M., Fan, Xingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Lens
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998144/
https://www.ncbi.nlm.nih.gov/pubmed/27472077
http://dx.doi.org/10.1167/iovs.16-19592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998144/
https://www.ncbi.nlm.nih.gov/pubmed/27472077
http://dx.doi.org/10.1167/iovs.16-19592

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