HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

During the early stages of infection, the HIV-1 capsid protects viral components from cytosolic sensors, such as cGAS, and nucleases, such as TREX, while allowing access to nucleotides for efficient reverse transcription1. Here we show that each capsid hexamer has a size-selective pore bounded by a...

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Detalles Bibliográficos
Autores principales: Jacques, David A., McEwan, William A., Hilditch, Laura, Price, Amanda J., Towers, Greg J., James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998957/
https://www.ncbi.nlm.nih.gov/pubmed/27509857
http://dx.doi.org/10.1038/nature19098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998957/
https://www.ncbi.nlm.nih.gov/pubmed/27509857
http://dx.doi.org/10.1038/nature19098

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