Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors

Experimental studies have shown that one key factor in driving the emergence of drug resistance in solid tumors is tumor hypoxia, which leads to the formation of localized environmental niches where drug-resistant cell populations can evolve and survive. Hypoxia-activated prodrugs (HAPs) are compoun...

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Detalles Bibliográficos
Autores principales: Lindsay, Danika, Garvey, Colleen M., Mumenthaler, Shannon M., Foo, Jasmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999195/
https://www.ncbi.nlm.nih.gov/pubmed/27560187
http://dx.doi.org/10.1371/journal.pcbi.1005077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999195/
https://www.ncbi.nlm.nih.gov/pubmed/27560187
http://dx.doi.org/10.1371/journal.pcbi.1005077

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