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Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors
Experimental studies have shown that one key factor in driving the emergence of drug resistance in solid tumors is tumor hypoxia, which leads to the formation of localized environmental niches where drug-resistant cell populations can evolve and survive. Hypoxia-activated prodrugs (HAPs) are compoun...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999195/ https://www.ncbi.nlm.nih.gov/pubmed/27560187 http://dx.doi.org/10.1371/journal.pcbi.1005077 |