Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

Inhibition of the protein-protein interaction (PPI) mediated by breast-cancer-gene 1 C-terminal (BRCT) is an attractive strategy to sensitize breast and ovarian cancers to chemotherapeutic agents that induce DNA damage. Such inhibitors could also be used for studies to understand the role of this PP...

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Detalles Bibliográficos
Autores principales: You, Wanli, Huang, Yu-ming M., Kizhake, Smitha, Natarajan, Amarnath, Chang, Chia-en A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999267/
https://www.ncbi.nlm.nih.gov/pubmed/27560145
http://dx.doi.org/10.1371/journal.pcbi.1005057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999267/
https://www.ncbi.nlm.nih.gov/pubmed/27560145
http://dx.doi.org/10.1371/journal.pcbi.1005057

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