Aurintricarboxylic acid structure modifications lead to reduction of inhibitory properties against virulence factor YopH and higher cytotoxicity

Yersinia sp. bacteria owe their viability and pathogenic virulence to the YopH factor, which is a highly active bacterial protein tyrosine phosphatase. Inhibition of YopH phosphatase results in the lack of Yersinia sp. pathogenicity. We have previously described that aurintricarboxylic acid inhibits...

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Detalles Bibliográficos
Autores principales: Kuban-Jankowska, Alicja, Sahu, Kamlesh K., Gorska, Magdalena, Niedzialkowski, Pawel, Tuszynski, Jack A., Ossowski, Tadeusz, Wozniak, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999467/
https://www.ncbi.nlm.nih.gov/pubmed/27562597
http://dx.doi.org/10.1007/s11274-016-2123-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999467/
https://www.ncbi.nlm.nih.gov/pubmed/27562597
http://dx.doi.org/10.1007/s11274-016-2123-3

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