Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Aims: Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its mo...

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Detalles Bibliográficos
Autores principales: Deas, Emma, Cremades, Nunilo, Angelova, Plamena R., Ludtmann, Marthe H.R., Yao, Zhi, Chen, Serene, Horrocks, Mathew H., Banushi, Blerida, Little, Daniel, Devine, Michael J., Gissen, Paul, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Gandhi, Sonia, Abramov, Andrey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Original Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999647/
https://www.ncbi.nlm.nih.gov/pubmed/26564470
http://dx.doi.org/10.1089/ars.2015.6343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999647/
https://www.ncbi.nlm.nih.gov/pubmed/26564470
http://dx.doi.org/10.1089/ars.2015.6343

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