Cargando…

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Aims: Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deas, Emma, Cremades, Nunilo, Angelova, Plamena R., Ludtmann, Marthe H.R., Yao, Zhi, Chen, Serene, Horrocks, Mathew H., Banushi, Blerida, Little, Daniel, Devine, Michael J., Gissen, Paul, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Gandhi, Sonia, Abramov, Andrey Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2016
Materias:	Original Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999647/ https://www.ncbi.nlm.nih.gov/pubmed/26564470 http://dx.doi.org/10.1089/ars.2015.6343

Ejemplares similares

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2016)

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
por: Ludtmann, Marthe H. R., et al.
Publicado: (2018)

Lipid peroxidation is essential for α‐synuclein‐induced cell death
por: Angelova, Plamena R., et al.
Publicado: (2015)

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
por: Reeve, A K, et al.
Publicado: (2015)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
por: Cascella, Roberta, et al.
Publicado: (2021)

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
por: Angelova, Plamena R., et al.
Publicado: (2020)

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
por: Tosatto, Laura, et al.
Publicado: (2015)

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale
por: Lee, Ji-Eun, et al.
Publicado: (2018)

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
por: Xu, Catherine K., et al.
Publicado: (2022)

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
por: Cremades, Nunilo, et al.
Publicado: (2012)

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
por: Horrocks, Mathew H., et al.
Publicado: (2016)

Optical Structural Analysis of Individual α‐Synuclein Oligomers
por: Varela, Juan A., et al.
Publicado: (2018)

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
por: Whiten, Daniel R., et al.
Publicado: (2018)

Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
por: Cascella, Roberta, et al.
Publicado: (2022)

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
por: Choi, Minee L., et al.
Publicado: (2022)

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
por: Iljina, Marija, et al.
Publicado: (2017)

Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
por: Choi, Minee L., et al.
Publicado: (2022)

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing
por: Pedersen, Jeppe T., et al.
Publicado: (2016)

Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
por: Limbocker, Ryan, et al.
Publicado: (2023)

Quantifying Co-Oligomer Formation by α-Synuclein
por: Iljina, Marija, et al.
Publicado: (2018)

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease
por: Gracia, Pablo, et al.
Publicado: (2020)

Overlapping Machinery in Lysosome-Related Organelle Trafficking: A Lesson from Rare Multisystem Disorders
por: Banushi, Blerida, et al.
Publicado: (2022)

A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics
por: Banushi, Blerida, et al.
Publicado: (2023)

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates
por: Camino, José D., et al.
Publicado: (2020)

LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation
por: Ludtmann, Marthe H. R., et al.
Publicado: (2019)

Correction: Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury
por: Siddall, Hilary K., et al.
Publicado: (2013)

Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury
por: Siddall, Hilary K., et al.
Publicado: (2013)

Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy
por: Bigi, Alessandra, et al.
Publicado: (2021)

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons
por: Kostic, Marko, et al.
Publicado: (2015)

Molecular pharmacology in a simple model system: Implicating MAP kinase and phosphoinositide signalling in bipolar disorder
por: Ludtmann, Marthe H.R., et al.
Publicado: (2011)

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
por: Santos, Jaime, et al.
Publicado: (2021)

Carbon monoxide neurotoxicity is triggered by oxidative stress induced by ROS production from three distinct cellular sources
por: Angelova, Plamena R., et al.
Publicado: (2023)

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
por: Shammas, Sarah L., et al.
Publicado: (2015)

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau
por: Gracia, Pablo, et al.
Publicado: (2022)

Lighting Up Alpha-synuclein Oligomers
por: Richter, Franziska
Publicado: (2018)

An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients
por: Kulenkampff, Klara, et al.
Publicado: (2022)

Inorganic polyphosphate is produced and hydrolyzed in F(0)F(1)-ATP synthase of mammalian mitochondria
por: Baev, Artyom Y., et al.
Publicado: (2020)

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
por: Limbocker, Ryan, et al.
Publicado: (2020)

Direct detection of alpha synuclein oligomers in vivo
por: Dimant, Hemi, et al.
Publicado: (2013)

Alpha-synuclein oligomers: a new hope
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_aredsvtgsghtuo7uqh1fmil7de