Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury

Exogenous Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective in animal models of brain injury, and has been considered as a potential therapeutic. Akt-mTOR and MAPK are downstream targets of IGF-1 signaling that are activated after brain injury. However, both brain injury and mTOR are linked to...

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Detalles Bibliográficos
Autores principales: Song, Yu, Pimentel, Corrin, Walters, Katherine, Boller, Lauren, Ghiasvand, Shabnam, Liu, Jing, Staley, Kevin J., Berdichevsky, Yevgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999804/
https://www.ncbi.nlm.nih.gov/pubmed/27561791
http://dx.doi.org/10.1038/srep32095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999804/
https://www.ncbi.nlm.nih.gov/pubmed/27561791
http://dx.doi.org/10.1038/srep32095

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