Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A

Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins that have been evaluated in clinical trials. Immunogenicity of the bacterial toxin and off-target toxicity have limited the efficacy of thes...

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Detalles Bibliográficos
Autores principales: Kaplan, Gilad, Lee, Fred, Onda, Masanori, Kolyvas, Emily, Bhardwaj, Gaurav, Baker, David, Pastan, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999843/
https://www.ncbi.nlm.nih.gov/pubmed/27463727
http://dx.doi.org/10.3390/toxins8080217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999843/
https://www.ncbi.nlm.nih.gov/pubmed/27463727
http://dx.doi.org/10.3390/toxins8080217

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