Cargando…

Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke

Fingolimod (FTY720) is an orally bio-available immunomodulatory drug currently approved by the FDA for the treatment of multiple sclerosis. Currently, there is a significant interest in the potential benefits of FTY720 on stroke outcomes. FTY720 and the sphingolipid signaling pathway it modulates ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wentao, Xu, Haoliang, Testai, Fernando D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999895/ https://www.ncbi.nlm.nih.gov/pubmed/27617002 http://dx.doi.org/10.3389/fneur.2016.00139

Ejemplares similares

Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage
por: Xu, Hao-Liang, et al.
Publicado: (2015)

Modulation of Cardiac Autonomic Function by Fingolimod Initiation and Predictors for Fingolimod Induced Bradycardia in Patients with Multiple Sclerosis
por: Li, Kai, et al.
Publicado: (2017)

Fingolimod for Irradiation-Induced Neurodegeneration
por: Metzdorf, Judith, et al.
Publicado: (2019)

Fingolimod for the treatment of neurological diseases—state of play and future perspectives
por: Brunkhorst, Robert, et al.
Publicado: (2014)

Increased Percentage of CD8(+)CD28(−) Regulatory T Cells With Fingolimod Therapy in Multiple Sclerosis
por: Houston, Timothy W., et al.
Publicado: (2022)

Determination of Seminal Concentration of Fingolimod and Fingolimod‐Phosphate in Multiple Sclerosis Patients Receiving Chronic Treatment With Fingolimod
por: David, Olivier J., et al.
Publicado: (2017)

A Case of Posterior Reversible Encephalopathy Syndrome Associated with Gilenya(®) (Fingolimod) Treatment for Multiple Sclerosis
por: Lindå, Hans, et al.
Publicado: (2015)

Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination in vivo Through a Non-immunomodulatory Mechanism
por: Zhang, Yuan, et al.
Publicado: (2019)

How Does Fingolimod (Gilenya(®)) Fit in the Treatment Algorithm for Highly Active Relapsing-Remitting Multiple Sclerosis?
por: Fazekas, Franz, et al.
Publicado: (2013)

Myeloid cells as target of fingolimod action in multiple sclerosis
por: Di Dario, Marco, et al.
Publicado: (2015)

Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center
por: Roux, Thomas, et al.
Publicado: (2017)

Fingolimod treatment modulates PPARγ and CD36 gene expression in women with multiple sclerosis
por: Ferret-Sena, Véronique, et al.
Publicado: (2022)

Fingolimod Inhibits Inflammation but Exacerbates Brain Edema in the Acute Phases of Cerebral Ischemia in Diabetic Mice
por: Li, Wanlu, et al.
Publicado: (2020)

FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment
por: Wang, Zifeng, et al.
Publicado: (2020)

Fingolimod Potentiates the Antifungal Activity of Amphotericin B
por: Wei, Lu-Qi, et al.
Publicado: (2021)

Neuroprotective Effects of Fingolimod Supplement on the Retina and Optic Nerve in the Mouse Model of Experimental Autoimmune Encephalomyelitis
por: Yang, Tao, et al.
Publicado: (2021)

Corrigendum: Combination therapy with fingolimod and neural stem cells promotes functional myelination in vivo through a non-immunomodulatory mechanism
por: Zhang, Yuan, et al.
Publicado: (2022)

Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod
por: Jęśko, Henryk, et al.
Publicado: (2021)

Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action
por: He, Ming-Chao, et al.
Publicado: (2022)

Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities
por: Diaz Diaz, Andrea C., et al.
Publicado: (2022)

Deep Brain Stimulation for Alzheimer's Disease: Stimulation Parameters and Potential Mechanisms of Action
por: Luo, Yinpei, et al.
Publicado: (2021)

From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod
por: Paudel, Yam Nath, et al.
Publicado: (2020)

The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars
por: Aoki, Masayo, et al.
Publicado: (2020)

Molecular Pharmacology and Novel Potential Therapeutic Applications of Fingolimod
por: Pournajaf, Safura, et al.
Publicado: (2022)

Evidence-based assessment of potential use of fingolimod in treatment of relapsing multiple sclerosis
por: Portaccio, Emilio
Publicado: (2011)

Vagomimetic Effects of Fingolimod: Physiology and Clinical Implications
por: Vanoli, Emilio, et al.
Publicado: (2014)

The Therapeutic Targets of Fingolimod (FTY720) Are Involved in Pathological Processes in the Frontal Cortex of Alzheimer's Disease Patients: A Network Pharmacology Study
por: Yin, Pengqi, et al.
Publicado: (2021)

Progressive multifocal leukoencephalopathy after fingolimod treatment
por: Berger, Joseph R., et al.
Publicado: (2018)

Therapeutic Hypothermia: Critical Review of the Molecular Mechanisms of Action
por: González-Ibarra, Fernando Pavel, et al.
Publicado: (2011)

The Electrically Evoked Compound Action Potential: From Laboratory to Clinic
por: He, Shuman, et al.
Publicado: (2017)

Single-Nucleus RNA-seq of Normal-Appearing Brain Regions in Relapsing-Remitting vs. Secondary Progressive Multiple Sclerosis: Implications for the Efficacy of Fingolimod
por: Kihara, Yasuyuki, et al.
Publicado: (2022)

Clinical efficacy, safety, and tolerability of fingolimod for the treatment of relapsing-remitting multiple sclerosis
por: Gajofatto, Alberto, et al.
Publicado: (2015)

The Mechanism and Clinical Application of Constraint-Induced Movement Therapy in Stroke Rehabilitation
por: Wang, Dong, et al.
Publicado: (2022)

Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis
por: Mills, Elizabeth A., et al.
Publicado: (2018)

The emerging role of FTY720 (Fingolimod) in cancer treatment
por: White, Christopher, et al.
Publicado: (2016)

Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis
por: Warnke, Clemens, et al.
Publicado: (2011)

Treatment satisfaction and quality of life in patients treated with fingolimod
por: Mékiès, Claude, et al.
Publicado: (2018)

Cryptococcal Meningitis Reported With Fingolimod Treatment: Case Series
por: Del Poeta, Maurizio, et al.
Publicado: (2022)

Fingolimod-Associated Macular Edema in the Treatment of Multiple Sclerosis
por: Khan, Asma A, et al.
Publicado: (2023)

Evaluation of Temozolomide and Fingolimod Treatments in Glioblastoma Preclinical Models
por: Davy, Mélodie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_r3befsbadtef8v2125biagsnbl