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TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation

BACKGROUND: Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. METHODS: In order t...

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Detalles Bibliográficos
Autores principales:	van Zoelen, Everardus J., Duarte, Isabel, Hendriks, José M., van der Woning, Sebastian P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000485/ https://www.ncbi.nlm.nih.gov/pubmed/27562730 http://dx.doi.org/10.1186/s13287-016-0375-3

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