Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells

Mutations to fibroblast growth factor receptor 3 (FGFR3) and phosphatase and tensin homologue (PTEN) signalling pathway components (for example, PTEN loss, PIK3CA, AKT1, TSC1/2) are common in bladder cancer, yet small-molecule inhibitors of these nodes (FGFR/PTENi) show only modest activity in precl...

Descripción completa

Detalles Bibliográficos
Autores principales: King, M A, Ganley, I G, Flemington, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000518/
https://www.ncbi.nlm.nih.gov/pubmed/26853465
http://dx.doi.org/10.1038/onc.2015.511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000518/
https://www.ncbi.nlm.nih.gov/pubmed/26853465
http://dx.doi.org/10.1038/onc.2015.511

Ejemplares similares