Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor

The binding of epidermal growth factor (EGF) to EGF receptor (EGFR) stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dime...

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Detalles Bibliográficos
Autores principales: Kourouniotis, George, Wang, Yi, Pennock, Steven, Chen, Xinmei, Wang, Zhixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000598/
https://www.ncbi.nlm.nih.gov/pubmed/27463710
http://dx.doi.org/10.3390/ijms17081200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000598/
https://www.ncbi.nlm.nih.gov/pubmed/27463710
http://dx.doi.org/10.3390/ijms17081200

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