Cargando…

Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor

The binding of epidermal growth factor (EGF) to EGF receptor (EGFR) stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dime...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kourouniotis, George, Wang, Yi, Pennock, Steven, Chen, Xinmei, Wang, Zhixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000598/ https://www.ncbi.nlm.nih.gov/pubmed/27463710 http://dx.doi.org/10.3390/ijms17081200

Ejemplares similares

Ligand regulation of a constitutively dimeric EGF receptor
por: Freed, Daniel M., et al.
Publicado: (2015)

EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo
por: Pinilla-Macua, Itziar, et al.
Publicado: (2017)

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling
por: Pascarelli, Stefano, et al.
Publicado: (2021)

An ultrasensitive sorting mechanism for EGF Receptor Endocytosis
por: Schmidt-Glenewinkel, Hannah, et al.
Publicado: (2008)

Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
por: Liu, Ning Sheng, et al.
Publicado: (2009)

Kinetics of binding, endocytosis, and recycling of EGF receptor mutants
Publicado: (1992)

Allosteric activation of preformed EGF receptor dimers by a single ligand binding event
por: Purba, Endang R., et al.
Publicado: (2022)

Differential Regulation of Transcription Factors by Location-Specific EGF Receptor Signaling via a Spatio-Temporal Interplay of ERK Activation
por: Wu, Peng, et al.
Publicado: (2012)

Correction: Differential Regulation of Transcription Factors by Location-Specific EGF Receptor Signaling via a Spatio-Temporal Interplay of ERK Activation
por: Wu, Peng, et al.
Publicado: (2013)

EGF receptor ligands: recent advances
por: Singh, Bhuminder, et al.
Publicado: (2016)

Lineage-specific co-evolution of the Egf receptor/ligand signaling system
por: Laisney, Juliette AGC, et al.
Publicado: (2010)

Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis
por: Vehlow, Anne, et al.
Publicado: (2013)

The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor
por: Wills, Melanie K. B., et al.
Publicado: (2014)

Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor
por: Swindle, C. Scott, et al.
Publicado: (2001)

Local signaling by the EGF receptor
por: Kempiak, Stephan J., et al.
Publicado: (2003)

Keratinocyte EGF signalling dominates in atopic dermatitis lesions: A comparative RNAseq analysis
por: Timms, Kate, et al.
Publicado: (2022)

Actin assembly produces sufficient forces for endocytosis in yeast
por: Nickaeen, Masoud, et al.
Publicado: (2019)

Epidermal Growth Factor and Membrane Trafficking: Egf Receptor Activation of Endocytosis Requires Rab5a
por: Barbieri, M. Alejandro, et al.
Publicado: (2000)

The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane
por: Tanno, Hidetaka, et al.
Publicado: (2012)

Activation of signaling receptors: do ligands bind to receptor monomer, dimer, or both?
por: Pang, Xiaodong, et al.
Publicado: (2013)

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras
por: Liang, Samantha I., et al.
Publicado: (2018)

ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin
por: Hosur, Vishnu, et al.
Publicado: (2018)

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”
por: Purba, Endang R., et al.
Publicado: (2017)

STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines
por: Zhou, W, et al.
Publicado: (2006)

EGF receptor trafficking: consequences for signaling and cancer
por: Tomas, Alejandra, et al.
Publicado: (2014)

Autophagy processes are dependent on EGF receptor signaling
por: De Iuliis, Vincenzo, et al.
Publicado: (2018)

Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell-signaling
por: Hu, Jingjing, et al.
Publicado: (2014)

Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor
por: Arkhipov, Anton, et al.
Publicado: (2014)

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
por: Greene, Maxwell, et al.
Publicado: (2016)

Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos
por: Koca, Yildiz, et al.
Publicado: (2019)

Quantum dots implementation as a label for analysis of early stages of EGF receptor endocytosis: a comparative study on cultured cells
por: Salova, Anna V., et al.
Publicado: (2015)

D-Cbl Binding to Drk Leads to Dose-Dependent Down-Regulation of EGFR Signaling and Increases Receptor-Ligand Endocytosis
por: Wang, Pei-Yu, et al.
Publicado: (2011)

Regulation of EGFR Endocytosis by CBL During Mitosis
por: Wee, Ping, et al.
Publicado: (2018)

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity
por: Opaliński, Łukasz, et al.
Publicado: (2017)

Effect of Spatial Inhomogeneities on the Membrane Surface on Receptor Dimerization and Signal Initiation
por: Kerketta, Romica, et al.
Publicado: (2016)

EGF Receptor Exposed to Oxidative Stress Acquires Abnormal Phosphorylation and Aberrant Activated Conformation That Impairs Canonical Dimerization
por: Filosto, Simone, et al.
Publicado: (2011)

Gefitinib Induces Epidermal Growth Factor Receptor Dimers Which Alters the Interaction Characteristics with (125)I-EGF
por: Björkelund, Hanna, et al.
Publicado: (2011)

Role of endocytosis and trans‐endocytosis in ICOS costimulator‐induced downmodulation of the ICOS Ligand
por: Aragoneses‐Fenoll, Laura, et al.
Publicado: (2021)

Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis
por: Larsen, Mads Breum, et al.
Publicado: (2019)

Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo
por: Yu, Xiao-Wen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jka5e49av3rrvbra4700ti55hp