SMA Human iPSC-Derived Motor Neurons Show Perturbed Differentiation and Reduced miR-335-5p Expression

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by mutations in the Survival Motor Neuron 1 gene, resulting in very low levels of functional Survival of Motor Neuron (SMN) protein. SMA human induced Pluripotent Stem Cells (hiPSCs) represent a useful and valid model for the study of t...

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Detalles Bibliográficos
Autores principales: Murdocca, Michela, Ciafrè, Silvia Anna, Spitalieri, Paola, Talarico, Rosa Valentina, Sanchez, Massimo, Novelli, Giuseppe, Sangiuolo, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000629/
https://www.ncbi.nlm.nih.gov/pubmed/27483257
http://dx.doi.org/10.3390/ijms17081231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000629/
https://www.ncbi.nlm.nih.gov/pubmed/27483257
http://dx.doi.org/10.3390/ijms17081231

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