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SMA Human iPSC-Derived Motor Neurons Show Perturbed Differentiation and Reduced miR-335-5p Expression
Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by mutations in the Survival Motor Neuron 1 gene, resulting in very low levels of functional Survival of Motor Neuron (SMN) protein. SMA human induced Pluripotent Stem Cells (hiPSCs) represent a useful and valid model for the study of t...
Autores principales: | Murdocca, Michela, Ciafrè, Silvia Anna, Spitalieri, Paola, Talarico, Rosa Valentina, Sanchez, Massimo, Novelli, Giuseppe, Sangiuolo, Federica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000629/ https://www.ncbi.nlm.nih.gov/pubmed/27483257 http://dx.doi.org/10.3390/ijms17081231 |
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