Synthesis and Cytotoxicity against K562 Cells of 3-O-Angeloyl-20-O-acetyl Ingenol, a Derivative of Ingenol Mebutate

Ingenol mebutate possesses significant cytotoxicity and is clinically used to treat actinic keratosis. However, ingenol mebutate undergoes acyl migration which affects its bioactivity. Compound 3-O-angeloyl-20-O-acetyl ingenol (AAI, also known as 20-O-acetyl-ingenol-3-angelate or PEP008) is a synthe...

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Detalles Bibliográficos
Autores principales: Liu, Ming, Chen, Fangling, Yu, Rilei, Zhang, Weiyi, Han, Mei, Liu, Fei, Wu, Jing, Zhao, Xingzeng, Miao, Jinlai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000744/
https://www.ncbi.nlm.nih.gov/pubmed/27548156
http://dx.doi.org/10.3390/ijms17081348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000744/
https://www.ncbi.nlm.nih.gov/pubmed/27548156
http://dx.doi.org/10.3390/ijms17081348

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