Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced K(ATP) Channel Activity

Aging is accompanied by impaired glucose homeostasis and an increased risk of type 2 diabetes, culminating in the failure of insulin secretion from pancreatic β-cells. To investigate the effects of age on β-cell metabolism, we established a novel assay to directly image islet metabolism with NAD(P)H...

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Detalles Bibliográficos
Autores principales: Gregg, Trillian, Poudel, Chetan, Schmidt, Brian A., Dhillon, Rashpal S., Sdao, Sophia M., Truchan, Nathan A., Baar, Emma L., Fernandez, Luis A., Denu, John M., Eliceiri, Kevin W., Rogers, Jeremy D., Kimple, Michelle E., Lamming, Dudley W., Merrins, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001174/
https://www.ncbi.nlm.nih.gov/pubmed/27284112
http://dx.doi.org/10.2337/db16-0432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001174/
https://www.ncbi.nlm.nih.gov/pubmed/27284112
http://dx.doi.org/10.2337/db16-0432

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