Structure-guided selection of specificity determining positions in the human Kinome

BACKGROUND: The human kinome contains many important drug targets. It is well-known that inhibitors of protein kinases bind with very different selectivity profiles. This is also the case for inhibitors of many other protein families. The increased availability of protein 3D structures has provided...

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Detalles Bibliográficos
Autores principales: Moll, Mark, Finn, Paul W., Kavraki, Lydia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001202/
https://www.ncbi.nlm.nih.gov/pubmed/27556159
http://dx.doi.org/10.1186/s12864-016-2790-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001202/
https://www.ncbi.nlm.nih.gov/pubmed/27556159
http://dx.doi.org/10.1186/s12864-016-2790-3

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