Statistical modeling for sensitive detection of low-frequency single nucleotide variants

BACKGROUND: Sensitive detection of low-frequency single nucleotide variants carries great significance in many applications. In cancer genetics research, tumor biopsies are a mixture of normal and tumor cells from various subpopulations due to tumor heterogeneity. Thus the frequencies of somatic var...

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Detalles Bibliográficos
Autores principales: Hao, Yangyang, Zhang, Pengyue, Xuei, Xiaoling, Nakshatri, Harikrishna, Edenberg, Howard J., Li, Lang, Liu, Yunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001245/
https://www.ncbi.nlm.nih.gov/pubmed/27556804
http://dx.doi.org/10.1186/s12864-016-2905-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001245/
https://www.ncbi.nlm.nih.gov/pubmed/27556804
http://dx.doi.org/10.1186/s12864-016-2905-x

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