Splice-switching antisense oligonucleotides as therapeutic drugs

Splice-switching oligonucleotides (SSOs) are short, synthetic, antisense, modified nucleic acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of the transcript by blocking the RNA–RNA base-pairing or protein–RNA binding interactions that occur between components of the s...

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Detalles Bibliográficos
Autores principales: Havens, Mallory A., Hastings, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001604/
https://www.ncbi.nlm.nih.gov/pubmed/27288447
http://dx.doi.org/10.1093/nar/gkw533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001604/
https://www.ncbi.nlm.nih.gov/pubmed/27288447
http://dx.doi.org/10.1093/nar/gkw533

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