Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t(6)A biosynthesis

KEOPS is an ancient protein complex required for the biosynthesis of N6-threonylcarbamoyladenosine (t(6)A), a universally conserved tRNA modification found on all ANN-codon recognizing tRNAs. KEOPS consist minimally of four essential subunits, namely the proteins Kae1, Bud32, Cgi121 and Pcc1, with y...

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Detalles Bibliográficos
Autores principales: Wan, Leo C.K., Pillon, Monica C., Thevakumaran, Neroshan, Sun, Yulong, Chakrabartty, Avi, Guarné, Alba, Kurinov, Igor, Durocher, Daniel, Sicheri, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001605/
https://www.ncbi.nlm.nih.gov/pubmed/27302132
http://dx.doi.org/10.1093/nar/gkw542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001605/
https://www.ncbi.nlm.nih.gov/pubmed/27302132
http://dx.doi.org/10.1093/nar/gkw542

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