Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

BACKGROUND: G-protein-coupled bile acid receptor 1, also known as TGR5 is known to be involved in glucose homeostasis. In animal models, treatment with a TGR5 agonist induces incretin secretion to reduce hyperglycemia. Betulinic acid, a triterpenoid present in the leaves of white birch, has been int...

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Detalles Bibliográficos
Autores principales: Lo, Shih-Hsiang, Cheng, Kai-Chung, Li, Ying-Xiao, Chang, Chin-Hong, Cheng, Juei-Tang, Lee, Kung-Shing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001664/
https://www.ncbi.nlm.nih.gov/pubmed/27578964
http://dx.doi.org/10.2147/DDDT.S113197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001664/
https://www.ncbi.nlm.nih.gov/pubmed/27578964
http://dx.doi.org/10.2147/DDDT.S113197

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