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Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay

BACKGROUND: G-protein-coupled bile acid receptor 1, also known as TGR5 is known to be involved in glucose homeostasis. In animal models, treatment with a TGR5 agonist induces incretin secretion to reduce hyperglycemia. Betulinic acid, a triterpenoid present in the leaves of white birch, has been int...

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Detalles Bibliográficos
Autores principales:	Lo, Shih-Hsiang, Cheng, Kai-Chung, Li, Ying-Xiao, Chang, Chin-Hong, Cheng, Juei-Tang, Lee, Kung-Shing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001664/ https://www.ncbi.nlm.nih.gov/pubmed/27578964 http://dx.doi.org/10.2147/DDDT.S113197

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