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Lesion orientation of O(4)-alkylthymidine influences replication by human DNA polymerase η

DNA lesions that elude repair may undergo translesion synthesis catalyzed by Y-family DNA polymerases. O(4)-Alkylthymidines, persistent adducts that can result from carcinogenic agents, may be encountered by DNA polymerases. The influence of lesion orientation around the C4–O(4) bond on processing b...

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Detalles Bibliográficos
Autores principales: O'Flaherty, D. K., Patra, A., Su, Y., Guengerich, F. P., Egli, M., Wilds, C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001687/
https://www.ncbi.nlm.nih.gov/pubmed/27574558
http://dx.doi.org/10.1039/c6sc00666c