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Lesion orientation of O(4)-alkylthymidine influences replication by human DNA polymerase η
DNA lesions that elude repair may undergo translesion synthesis catalyzed by Y-family DNA polymerases. O(4)-Alkylthymidines, persistent adducts that can result from carcinogenic agents, may be encountered by DNA polymerases. The influence of lesion orientation around the C4–O(4) bond on processing b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001687/ https://www.ncbi.nlm.nih.gov/pubmed/27574558 http://dx.doi.org/10.1039/c6sc00666c |