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Lesion orientation of O(4)-alkylthymidine influences replication by human DNA polymerase η

DNA lesions that elude repair may undergo translesion synthesis catalyzed by Y-family DNA polymerases. O(4)-Alkylthymidines, persistent adducts that can result from carcinogenic agents, may be encountered by DNA polymerases. The influence of lesion orientation around the C4–O(4) bond on processing b...

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Detalles Bibliográficos
Autores principales:	O'Flaherty, D. K., Patra, A., Su, Y., Guengerich, F. P., Egli, M., Wilds, C. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001687/ https://www.ncbi.nlm.nih.gov/pubmed/27574558 http://dx.doi.org/10.1039/c6sc00666c

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