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Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis
BACKGROUND: Data from multiple sclerosis (MS) and the MS rodent model, experimental autoimmune encephalomyelitis (EAE), highlighted an inflammation-dependent synaptopathy at the basis of the neurodegenerative damage causing irreversible disability in these disorders. This synaptopathy is characteriz...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002118/ https://www.ncbi.nlm.nih.gov/pubmed/27566665 http://dx.doi.org/10.1186/s12974-016-0686-4 |