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USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

The ubiquitin–proteasome system (UPS) and autophagy are two major intracellular degradative mechanisms that mediate the turnover of complementary repertoires of intracellular proteomes. Simultaneously activating both UPS and autophagy might provide a powerful strategy for the clearance of misfolded...

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Detalles Bibliográficos
Autores principales: Xu, Daichao, Shan, Bing, Sun, Huawang, Xiao, Juan, Zhu, Kezhou, Xie, Xingxing, Li, Xingyan, Liang, Wei, Lu, Xiaojuan, Qian, Lihui, Yuan, Junying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002977/
https://www.ncbi.nlm.nih.gov/pubmed/27542828
http://dx.doi.org/10.1101/gad.285122.116