Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants

HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2(S306A) mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Gieldon, Artur, Zurawa-Janicka, Dorota, Jarzab, Miroslaw, Wenta, Tomasz, Golik, Przemyslaw, Dubin, Grzegorz, Lipinska, Barbara, Ciarkowski, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003398/
https://www.ncbi.nlm.nih.gov/pubmed/27571206
http://dx.doi.org/10.1371/journal.pone.0161526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003398/
https://www.ncbi.nlm.nih.gov/pubmed/27571206
http://dx.doi.org/10.1371/journal.pone.0161526

Ejemplares similares