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Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants
HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2(S306A) mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003398/ https://www.ncbi.nlm.nih.gov/pubmed/27571206 http://dx.doi.org/10.1371/journal.pone.0161526 |