Synergistic and complete reversal of the multidrug resistance of mitoxantrone hydrochloride by three-in-one multifunctional lipid-sodium glycocholate nanocarriers based on simultaneous BCRP and Bcl-2 inhibition

Multidrug resistance (MDR) is a severe obstacle to successful chemotherapy due to its complicated nature that involves multiple mechanisms, such as drug efflux by transporters (P-glycoprotein and breast cancer resistance protein, BCRP) and anti-apoptotic defense (B-cell lymphoma, Bcl-2). To synergis...

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Detalles Bibliográficos
Autores principales: Ling, Guixia, Zhang, Tianhong, Zhang, Peng, Sun, Jin, He, Zhonggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003557/
https://www.ncbi.nlm.nih.gov/pubmed/27601896
http://dx.doi.org/10.2147/IJN.S95767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003557/
https://www.ncbi.nlm.nih.gov/pubmed/27601896
http://dx.doi.org/10.2147/IJN.S95767

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