Burkitt’s lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis

Burkitt’s Lymphomas (BLs) acquire consistent point mutations in a conserved domain of Myc, Myc Box I. We report that the enhanced transforming activity of BL-associated Myc mutants can be uncoupled from loss of phosphorylation and increased protein stability. Furthermore, two different BL-associated...

Descripción completa

Detalles Bibliográficos
Autores principales: Cowling, Victoria H., Turner, Scott A., Cole, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003617/
https://www.ncbi.nlm.nih.gov/pubmed/24013231
http://dx.doi.org/10.1038/onc.2013.338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003617/
https://www.ncbi.nlm.nih.gov/pubmed/24013231
http://dx.doi.org/10.1038/onc.2013.338

Ejemplares similares