ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

Modeling Amyotrophic Lateral Sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation, and aging of spinal motor neurons (spMNs) in vitro. As the maturity of spMNs grown in vitro compared to spMNs in vivo remains largely unaddressed, it is unclear t...

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Detalles Bibliográficos
Autores principales: Ho, Ritchie, Sances, Samuel, Gowing, Genevieve, Amoroso, Mackenzie Weygandt, O'Rourke, Jacqueline G., Sahabian, Anais, Wichterle, Hynek, Baloh, Robert H., Sareen, Dhruv, Svendsen, Clive N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003654/
https://www.ncbi.nlm.nih.gov/pubmed/27428653
http://dx.doi.org/10.1038/nn.4345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003654/
https://www.ncbi.nlm.nih.gov/pubmed/27428653
http://dx.doi.org/10.1038/nn.4345

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