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Diminished KCC2 confounds synapse-specificity of LTP during senescence
Synapse-specificity of LTP ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21-28 months-old) mice LTP was relayed to unstimulated synapses blemishing its synapse-specificity. Diminished levels of the K(+)/Cl(–) cotransporter KCC2 and a d...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003660/ https://www.ncbi.nlm.nih.gov/pubmed/27500406 http://dx.doi.org/10.1038/nn.4357 |