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Diminished KCC2 confounds synapse-specificity of LTP during senescence

Synapse-specificity of LTP ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21-28 months-old) mice LTP was relayed to unstimulated synapses blemishing its synapse-specificity. Diminished levels of the K(+)/Cl(–) cotransporter KCC2 and a d...

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Detalles Bibliográficos
Autores principales:	Ferando, Isabella, Faas, Guido, Mody, Istvan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003660/ https://www.ncbi.nlm.nih.gov/pubmed/27500406 http://dx.doi.org/10.1038/nn.4357

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