Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes

Nuclear DNA is the target responsible for anticancer activity of platinum anticancer drugs. Their activity is mediated by altered signals related to programmed cell death and the activation of various signaling pathways. An example is activation of nuclear factor kappaB (NF-κB). Binding of NF-κB pro...

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Detalles Bibliográficos
Autores principales: Brabec, Viktor, Kasparkova, Jana, Kostrhunova, Hana, Farrell, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004165/
https://www.ncbi.nlm.nih.gov/pubmed/27574114
http://dx.doi.org/10.1038/srep28474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004165/
https://www.ncbi.nlm.nih.gov/pubmed/27574114
http://dx.doi.org/10.1038/srep28474

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