A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells

The selectivity of (4Z)-2-(4-chloro-3-nitrophenyl)-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one (DI) for zipper-interacting protein kinase (ZIPK) was previously described by in silico computational modeling, screening a large panel of kinases, and determining the inhibition efficacy. Our assessment...

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Detalles Bibliográficos
Autores principales: Al-Ghabkari, Abdulhameed, Deng, Jing-Ti, McDonald, Paul C., Dedhar, Shoukat, Alshehri, Mana, Walsh, Michael P., MacDonald, Justin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004178/
https://www.ncbi.nlm.nih.gov/pubmed/27573465
http://dx.doi.org/10.1038/srep32118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004178/
https://www.ncbi.nlm.nih.gov/pubmed/27573465
http://dx.doi.org/10.1038/srep32118

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