Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification

The spiro[pyrrolidine-3, 3´-oxindole] moiety is present as a core in number of alkaloids with substantial biological activities. Here in we report design and synthesis of a library of compounds bearing spiro[pyrrolidine-3, 3´-oxindole] motifs that demonstrated exceptional inhibitory activity against...

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Detalles Bibliográficos
Autores principales: Hati, Santanu, Tripathy, Sayantan, Dutta, Pratip Kumar, Agarwal, Rahul, Srinivasan, Ramprasad, Singh, Ashutosh, Singh, Shailja, Sen, Subhabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004205/
https://www.ncbi.nlm.nih.gov/pubmed/27573798
http://dx.doi.org/10.1038/srep32213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004205/
https://www.ncbi.nlm.nih.gov/pubmed/27573798
http://dx.doi.org/10.1038/srep32213

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