Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids

Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but interaction of bulk anionic phospholipid (PL(−)) wit...

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Detalles Bibliográficos
Autores principales: Lee, Sun-Joo, Ren, Feifei, Zangerl-Plessl, Eva-Maria, Heyman, Sarah, Stary-Weinzinger, Anna, Yuan, Peng, Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004336/
https://www.ncbi.nlm.nih.gov/pubmed/27527100
http://dx.doi.org/10.1085/jgp.201611616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004336/
https://www.ncbi.nlm.nih.gov/pubmed/27527100
http://dx.doi.org/10.1085/jgp.201611616

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