Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion

Macropinocytosis, the internalization of extracellular fluid and material by plasma membrane ruffles, is critical for antigen presentation, cell metabolism, and signaling. Macropinosomes mature through homotypic and heterotypic fusion with endosomes and ultimately merge with lysosomes. The molecular...

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Detalles Bibliográficos
Autores principales: Dolat, Lee, Spiliotis, Elias T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004444/
https://www.ncbi.nlm.nih.gov/pubmed/27551056
http://dx.doi.org/10.1083/jcb.201603030