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AβPP processing results in greater toxicity per amount of Aβ(1-42) than individually expressed and secreted Aβ(1-42) in Drosophila melanogaster
The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing of the transmembrane Aβ precursor protein (AβPP) via sequential proteolysis throug...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004604/ https://www.ncbi.nlm.nih.gov/pubmed/27387531 http://dx.doi.org/10.1242/bio.017194 |