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AβPP processing results in greater toxicity per amount of Aβ(1-42) than individually expressed and secreted Aβ(1-42) in Drosophila melanogaster

The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing of the transmembrane Aβ precursor protein (AβPP) via sequential proteolysis throug...

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Detalles Bibliográficos
Autores principales:	Bergkvist, Liza, Sandin, Linnea, Kågedal, Katarina, Brorsson, Ann-Christin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004604/ https://www.ncbi.nlm.nih.gov/pubmed/27387531 http://dx.doi.org/10.1242/bio.017194

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