Probing extracellular Sonic hedgehog in neurons

The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in extracellular space. Multiple lines of evidenc...

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Detalles Bibliográficos
Autores principales: Eitan, Erez, Petralia, Ronald S., Wang, Ya-Xian, Indig, Fred E., Mattson, Mark P., Yao, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004615/
https://www.ncbi.nlm.nih.gov/pubmed/27387534
http://dx.doi.org/10.1242/bio.019422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004615/
https://www.ncbi.nlm.nih.gov/pubmed/27387534
http://dx.doi.org/10.1242/bio.019422

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