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Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors
EZH2, the main catalytic component of the Polycomb Repressive Complex 2 (PRC2) is apparently upregulated in most solid tumors. Furthermore its expression generally associates with poor prognosis. It was proposed that this correlation reflects a causal event, EZH2 mediating the silencing of key tumor...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004685/ https://www.ncbi.nlm.nih.gov/pubmed/27419533 http://dx.doi.org/10.1080/15384101.2016.1208872 |