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VAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study

Salvage chemotherapy (CT) for relapsing or refractory small cell lung cancer (SCLC) remains disappointing. In vitro experiments showed that valproic acid increases apoptosis of SCLC cell lines exposed to doxorubicin, vindesine and bis(2-chloroethyl)amine. The primary objective of this phase II study...

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Detalles Bibliográficos
Autores principales: Berghmans, Thierry, Lafitte, Jean-Jacques, Scherpereel, Arnaud, Ameye, Lieveke, Paesmans, Marianne, Meert, Anne-Pascale, Colinet, Benoit, Tulippe, Christian, Willems, Luc, Leclercq, Nathalie, Sculier, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005117/
https://www.ncbi.nlm.nih.gov/pubmed/27730152
http://dx.doi.org/10.1183/23120541.00029-2015