Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma

The epigenetic modifier EZH2 is in the center of a repressive complex controlling differentiation of normal cells. In cancer EZH2 has been implicated in silencing tumor suppressor genes. Its role in melanoma as well as target genes affected by EZH2 are poorly understood. In view of this we have used...

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Detalles Bibliográficos
Autores principales: Tiffen, Jessamy, Wilson, Stephen, Gallagher, Stuart J., Hersey, Peter, Filipp, Fabian V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005314/
https://www.ncbi.nlm.nih.gov/pubmed/26936398
http://dx.doi.org/10.1016/j.neo.2016.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005314/
https://www.ncbi.nlm.nih.gov/pubmed/26936398
http://dx.doi.org/10.1016/j.neo.2016.01.003

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