Cargando…

Effect of HSV-IL12 Loaded Tumor Cell-Based Vaccination in a Mouse Model of High-Grade Neuroblastoma

We designed multimodal tumor vaccine that consists of irradiated tumor cells infected with the oncolytic IL-12-expressing HSV-1 virus, M002. This vaccine was tested against the syngeneic neuroblastoma mouse model Neuro 2a injected into the right caudate nucleus of the immunocompetent A/J mice. Mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bauer, David F., Pereboeva, Larisa, Gillespie, G. Yancey, Cloud, Gretchen A., Elzafarany, Osama, Langford, Catherine, Markert, James M., Jr., Lawrence S. Lamb
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005549/ https://www.ncbi.nlm.nih.gov/pubmed/27610392 http://dx.doi.org/10.1155/2016/2568125

Ejemplares similares

A combined treatment regimen of MGMT-modified γδ T cells and temozolomide chemotherapy is effective against primary high grade gliomas
por: Lamb, Lawrence S., et al.
Publicado: (2021)

Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma
por: Beck, Benjamin H., et al.
Publicado: (2015)

Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapy
por: Friedman, Gregory K., et al.
Publicado: (2013)

Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression
por: Friedman, Gregory K., et al.
Publicado: (2018)

γ(1)34.5-Deleted HSV-1 Expressing Human Cytomegalovirus IRS1 Gene Kills Human Glioblastoma Cells as Efficiently as Wild-type HSV-1 in Normoxia or Hypoxia
por: Friedman, Gregory K., et al.
Publicado: (2014)

CMV-Independent Lysis of Glioblastoma by Ex Vivo Expanded/Activated Vδ1+ γδ T Cells
por: Knight, Andrea, et al.
Publicado: (2013)

The One Health Consortium: Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Combination With a Checkpoint Inhibitor in Canine Patients With Sporadic High Grade Gliomas
por: Chambers, M. R., et al.
Publicado: (2020)

Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas
por: Oliva, Claudia R., et al.
Publicado: (2015)

DNA Damage Responses and Oxidative Stress in Dyskeratosis Congenita
por: Pereboeva, Larisa, et al.
Publicado: (2013)

Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002
por: Ring, Eric K., et al.
Publicado: (2017)

Chimeric HCMV/HSV-1 and Δγ(1)34.5 oncolytic herpes simplex virus elicit immune mediated antigliomal effect and antitumor memory()()
por: Ghonime, Mohammed G., et al.
Publicado: (2017)

Curing glioblastoma: oncolytic HSV-IL12 and checkpoint blockade
por: Saha, Dipongkor, et al.
Publicado: (2017)

IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in mice
por: Thomas, Eric D., et al.
Publicado: (2016)

Preclinical Evaluation of Engineered Oncolytic Herpes Simplex Virus for the Treatment of Neuroblastoma
por: Gillory, Lauren A., et al.
Publicado: (2013)

Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
por: Cho, Hyun-Sang, et al.
Publicado: (2004)

Combination strategies enhance oncolytic virotherapy
por: Friedman, Gregory K., et al.
Publicado: (2017)

Mangiferin-Loaded Smart Gels for HSV-1 Treatment
por: Sicurella, Mariaconcetta, et al.
Publicado: (2021)

Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12
por: Barker, S E, et al.
Publicado: (2007)

In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia
por: Minagawa, Kentaro, et al.
Publicado: (2016)

Correction: In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia
por: Minagawa, Kentaro, et al.
Publicado: (2017)

Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12
por: Siapati, K E, et al.
Publicado: (2003)

Preclinical Evaluation of Oncolytic Δγ (1)34.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases
por: Cody, James J., et al.
Publicado: (2012)

IL-2 Suppression of IL-12p70 by a Recombinant HSV-1 Expressing IL-2 Induces T-Cell Auto-Reactivity and CNS Demyelination
por: Zandian, Mandana, et al.
Publicado: (2011)

Engineered Drug Resistant γδ T Cells Kill Glioblastoma Cell Lines during a Chemotherapy Challenge: A Strategy for Combining Chemo- and Immunotherapy
por: Lamb, Lawrence S., et al.
Publicado: (2013)

Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor
por: Komarova, Svetlana, et al.
Publicado: (2010)

Robust DNA Damage Response and Elevated Reactive Oxygen Species in TINF2-Mutated Dyskeratosis Congenita Cells
por: Pereboeva, Larisa, et al.
Publicado: (2016)

Blocking PD1/PDL1 Interactions Together with MLN4924 Therapy is a Potential Strategy for Glioma Treatment
por: Filippova, Natalia, et al.
Publicado: (2018)

HSV-1 miR-H6 Inhibits HSV-1 Replication and IL-6 Expression in Human Corneal Epithelial Cells In Vitro
por: Duan, Fang, et al.
Publicado: (2012)

Ocular infection of mice with an avirulent recombinant HSV-1 expressing IL-4 and an attenuated HSV-1 strain generates virulent recombinants in vivo
por: Mott, Kevin R., et al.
Publicado: (2010)

IL-25 Enhances HSV-1 Replication by Inhibiting Filaggrin Expression, and Acts Synergistically with T(H)2 Cytokines to Enhance HSV-1 Replication
por: Kim, Byung Eui, et al.
Publicado: (2013)

HSV-1 Modulates IL-6 Receptor Expression on Human Dendritic Cells
por: Birzer, Alexandra, et al.
Publicado: (2020)

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women
por: Gilbert, Peter B., et al.
Publicado: (2017)

Worldwide circulation of HSV-2 × HSV-1 recombinant strains
por: Koelle, David M., et al.
Publicado: (2017)

EPCT-22 SAFETY AND EFFICACY OF INTRAVENTRICULAR IMMUNOVIROTHERAPY WITH ONCOLYTIC HSV-1 G207 FOR TREATMENT OF LEPTOMENINGEAL DISEASE
por: Kang, Kyung-Don, et al.
Publicado: (2021)

IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination
por: Hirose, Satoshi, et al.
Publicado: (2023)

Targeting Pediatric Cancer Stem Cells with Oncolytic Virotherapy
por: Friedman, Gregory K., et al.
Publicado: (2012)

Use of "biokit HSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA
por: Morrow, Rhoda Ashley, et al.
Publicado: (2005)

Herpes simplex (HSV) viral load in bronchoalveolar lavage: risk factors and clinical outcome
por: Linssen, C.F.M., et al.
Publicado: (2006)

Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation
por: Peng, Tao, et al.
Publicado: (2017)

The combination therapy of oncolytic HSV-1 armed with anti-PD-1 antibody and IL-12 enhances anti-tumor efficacy
por: Xie, Xin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3ll5jfkbbm96j09iea9tqpb1i0